30.04.2025
Scientists from Bashkir State Medical University have developed a novel molecule aimed at treating myocardial infarction
This collaboration with Bashkir State Medical University and Hangzhou Normal University focuses on reducing cardiac tissue necrosis, significantly improving recovery prospects and minimizing complications for heart attack patients.
The molecule was created in the Bashkir State Medical University's laboratory as part of an international grant supported by China's National Natural Science Foundation and the Russian Scientific Foundation "Assessment of the role of deubiquiting enzymes in ischemia-reperfusion myocardial injury and development of cardioprotective agents."
The work of two research teams of the Bashkir Medical and Hangzhou Universities began in 2021. Work with Chinese colleagues is led by Professor Wang Yi, who is now an honorary professor at BSMU of the Russian Ministry of Health.
Within the framework of a new study, an interdisciplinary team of scientists from the BSMU of the Ministry of Health of Russia, under the supervision of Doctor of Medical Sciences, Professor Alexander Samorodov, together with colleagues from China, identified the role of ubiquitin in both the development and progression of ischemic myocardial damage.
«Ubiquitin is a protein that plays an important role in our body, helping to get rid of damaged cells. With myocardial ischemia (when the heart muscle does not receive enough oxygen due to impaired blood supply), heart cells are damaged. "Ubiquitin, by identifying damaged cells, plays a key role in the regulation of programmed cell death (apoptosis) in such conditions», the project's director, Doctor of Medical Sciences, Professor Alexander Samorodov explained.
Ubiquitin helps eliminate damaged cells during myocardial ischemia, and the newly discovered molecule functions by decreasing ubiquitin levels in "hibernating" myocardium—areas of the heart that temporarily lose function due to oxygen deprivation.
The new compound has shown high efficacy in early testing, with clinical trials planned for its potential application in medical practice. This research exemplifies the university's commitment to advancing medical knowledge and technologies through modern education and innovative scientific endeavors.
"Thanks to the work of modern research laboratories with high-tech world-class equipment, our university is implementing promising scientific areas that are already working to obtain medical knowledge and medical technologies of tomorrow.
Today, the country and the world need new medical products, new knowledge, medicine. Currently, the university is implementing a modern model of medical education, where the university sells not just the medical product or service itself, but the entire technology: from training a doctor, creating the technology and bringing it to the patient.
As a part of the Priority 2030 program, as well as with the support of the Russian Science Foundation, we have the opportunity to develop medications with unique mechanisms of action.
This not only strengthens the scientific potential of the Bashkir State Medical University, but also opens up new horizons for international cooperation. In this area, combining competencies, we actively interact with colleagues from Hangzhou Pedagogy University, working together on innovative projects to solve urgent problems of practical healthcare," - Rector of BSMU of the Ministry of Health of Russia, Academician of the Russian Academy of Sciences, Professor Valentin Pavlov .
Students from Bashkir Medical University, including foreign students and research residents, are engaged in a collaborative cardiopharmacology study. Renata Gabdrakhimova, a 5th-year student, highlighted that this scientific project offers a unique opportunity to deepen knowledge and contribute to meaningful advancements in medicine.
"Participation in a scientific project is a unique opportunity not only to deepen your knowledge, but also to make a real contribution to science. > Xenia Viktorovna: I see great prospects in our project - each experiment and each discovery brings us closer to new solutions that can change people's lives. I am sure that this work will become an important part of my professional career and will open doors to new opportunities in medicine", Renata Gabdrakhimova shared.
The research aims to refine traditional methods in cardiopharmacology, leading to new techniques for assessing myocardial damage. The interdisciplinary team is also developing a device for visualizing this damage.
With heart disease recognized by the WHO as a leading cause of death globally, this work addresses a critical health issue, as over 700,000 people die from myocardial infarction and its complications in Russia each year.
The molecule was created in the Bashkir State Medical University's laboratory as part of an international grant supported by China's National Natural Science Foundation and the Russian Scientific Foundation "Assessment of the role of deubiquiting enzymes in ischemia-reperfusion myocardial injury and development of cardioprotective agents."
The work of two research teams of the Bashkir Medical and Hangzhou Universities began in 2021. Work with Chinese colleagues is led by Professor Wang Yi, who is now an honorary professor at BSMU of the Russian Ministry of Health.
Within the framework of a new study, an interdisciplinary team of scientists from the BSMU of the Ministry of Health of Russia, under the supervision of Doctor of Medical Sciences, Professor Alexander Samorodov, together with colleagues from China, identified the role of ubiquitin in both the development and progression of ischemic myocardial damage.
«Ubiquitin is a protein that plays an important role in our body, helping to get rid of damaged cells. With myocardial ischemia (when the heart muscle does not receive enough oxygen due to impaired blood supply), heart cells are damaged. "Ubiquitin, by identifying damaged cells, plays a key role in the regulation of programmed cell death (apoptosis) in such conditions», the project's director, Doctor of Medical Sciences, Professor Alexander Samorodov explained.
Ubiquitin helps eliminate damaged cells during myocardial ischemia, and the newly discovered molecule functions by decreasing ubiquitin levels in "hibernating" myocardium—areas of the heart that temporarily lose function due to oxygen deprivation.
The new compound has shown high efficacy in early testing, with clinical trials planned for its potential application in medical practice. This research exemplifies the university's commitment to advancing medical knowledge and technologies through modern education and innovative scientific endeavors.
"Thanks to the work of modern research laboratories with high-tech world-class equipment, our university is implementing promising scientific areas that are already working to obtain medical knowledge and medical technologies of tomorrow.
Today, the country and the world need new medical products, new knowledge, medicine. Currently, the university is implementing a modern model of medical education, where the university sells not just the medical product or service itself, but the entire technology: from training a doctor, creating the technology and bringing it to the patient.
As a part of the Priority 2030 program, as well as with the support of the Russian Science Foundation, we have the opportunity to develop medications with unique mechanisms of action.
This not only strengthens the scientific potential of the Bashkir State Medical University, but also opens up new horizons for international cooperation. In this area, combining competencies, we actively interact with colleagues from Hangzhou Pedagogy University, working together on innovative projects to solve urgent problems of practical healthcare," - Rector of BSMU of the Ministry of Health of Russia, Academician of the Russian Academy of Sciences, Professor Valentin Pavlov .
Students from Bashkir Medical University, including foreign students and research residents, are engaged in a collaborative cardiopharmacology study. Renata Gabdrakhimova, a 5th-year student, highlighted that this scientific project offers a unique opportunity to deepen knowledge and contribute to meaningful advancements in medicine.
"Participation in a scientific project is a unique opportunity not only to deepen your knowledge, but also to make a real contribution to science. > Xenia Viktorovna: I see great prospects in our project - each experiment and each discovery brings us closer to new solutions that can change people's lives. I am sure that this work will become an important part of my professional career and will open doors to new opportunities in medicine", Renata Gabdrakhimova shared.
The research aims to refine traditional methods in cardiopharmacology, leading to new techniques for assessing myocardial damage. The interdisciplinary team is also developing a device for visualizing this damage.
With heart disease recognized by the WHO as a leading cause of death globally, this work addresses a critical health issue, as over 700,000 people die from myocardial infarction and its complications in Russia each year.
