In connection with the expansion of the Department of Hospital Pediatrics, its reorganization and restructuring was repeatedly carried out: the Department of Pediatric Diseases No. 2 with courses of Endocrinology and Neonatology (1985-1990) – Head of the Department, Prof. R. G. Enikeev, Department of Neonatology and Perinatology (1991-1999) – Head of the Department, Prof. E. N. Akhmadeeva were allocated from the department.. The allocation of these departments was expedient not only due to changes in the curriculum, but also due to the fact that scientific directions in neonatology and pediatric endocrinology were widely developed at these departments.
In 1999, due to changes in the curriculum at the pediatric faculties of medical universities of Russia, the BSMU reorganized the graduating departments of the pediatric profile again: the Department of Pediatric Diseases No. 1 (Head – Prof. S.E. Belyaev) and the Department of Neonatology and Perinatology (Head – Prof. E.N. Akhmadeeva) were merged. Joint Department of Hospital Pediatrics with a course of polyclinic Pediatrics since 1999 led by Academician of the RAE, expert and adviser to the WHO Regional Office for Europe, member of the Council of the International Children's Center (ICC), member of the
Presidium of the RASP and Chairman of its Bashkir Branch, member of the Council of Experts on Child Nutrition of the Union of Pediatricians of Russia, Doctor of Medical Sciences Professor E.N. Akhmadeeva. Since April 2016, the head of the Department of Hospital Pediatrics has been Professor, Doctor of Medical Sciences, Chief freelance Pediatric Cardiorheumatologist of the Ministry of Health of the Republic of Bashkortostan, Professor V.A.Malievsky.
Currently, the department has a high scientific and pedagogical potential. The degree of the teachers of the department is 100%. The teaching staff of the department works in various areas of science and children's health - neonatology and perinatology (MD, Prof. Akhmadeeva E.N., MD, Prof. Amirova V.R., MD, Prof. Panova L.D., Associate Professor, Ph.D. Bryukhanova O.A., Associate Professor, Ph.D. A.Ya.Valiullina), Pediatric Nephrology – (MD, prof. Z.M. Enikeeva), Pediatric Cardiology (MD, prof. Malievsky V.A.), pediatric allergology, pulmonology, ENT diseases (MD, Prof. Gatiyatullin R.F.), pediatric gastroenterology (MD Nizhevich A.A.), pediatric endocrinology (MD, Prof. Malievsky O.A., Associate Professor, Candidate of Medical Sciences, Klimentyeva M.M.).
The educational and pedagogical process in the discipline "Hospital pediatrics" for students of the 6th year of the pediatric faculty and the medical and advisory work of the teachers of the Department of hospital Pediatrics are carried out at the modern equipped clinical bases: GBUZ Republican Children's Clinical Hospital (chief physician Semavina L.Yu.), Republican Perinatal Center (chief physician – I.S.Zasyadkin), GBUZ RB City Children 's Hospital No. 17Ufa (chief physician D.R. Shagieva).
The department conducts classes in elective disciplines – "Modern approaches to the care of underweight newborns", "Modern strategy for the diagnosis and treatment of diseases of young children", "Evidence-based medicine", "Immunopathology of childhood", "Antibacterial therapy in pediatrics" and "Differential diagnostic algorithms in pediatrics". Specialists are being trained in postgraduate studies, postgraduate training of clinical residents in the specialty "Pediatrics", "Neonatology" and "Pediatric Endocrinology" is being carried out.
Lectures and practical classes at the department are conducted using modern demonstration materials with the help of multimedia presentations, video equipment. Practical classes of students and training of clinical residents are conducted by teachers with the active participation of practical doctors of the clinic directly in the departments of the RDC of the somatic profile (department of pathology of newborns, pulmonology, allergology, cardiology, oncohematology, endocrinology, gastroenterology, nephrology departments. By order of the rector of BSMU Prof. Pavlova V.N. and in coordination with the chief physician of the RDCB Semavina L.Yu. the department organized the work of students and clinical residents in educational laboratories. The educational laboratory of the department is the functional divisions and laboratories of the RDCB – the immunological department, the departments of functional diagnostics, radiation diagnostics, physiotherapy, physical therapy, clinical and bacteriological laboratories.
Under the guidance of the teaching staff, the department is actively conducting research work. The student scientific circle on pediatrics is actively working at the department.
The department works in close cooperation with the teams of other medical universities of the Russian Federation (Russian State Medical University — RSMU, St. Petersburg Medical Academy of Postgraduate Education, Kazan Medical University, Kazan Medical Academy of Postgraduate Education, Astrakhan, Samara, Saratov, Perm, Chelyabinsk, Ural, Izhevsk, etc. medical academies), the All-Russian Research Center of Obstetrics-Gynecology and Perinatology (multicenter studies), foreign colleagues from Estonia, Sweden, Switzerland, Denmark, Norway. Teachers of the department traveled to America, Italy, Spain, Greece, Estonia, Sweden, Austria, Finland, China, France, the UAE, etc. to exchange experience of foreign colleagues. The Department actively cooperates with public organizations: the Russian Association of Perinatal Medicine Specialists (President – Academician of the Russian Academy of Sciences Professor Volodin Nikolay Nikolaevich), the Union of Pediatricians of Russia (President of the Russian Academy of Medical Sciences Professor Alexander Baranov), the Russian Society of Evidence–based Medicine Specialists (President - Professor D. Danishevsky), pharmaceutical campaigns.
Currently, the Department of Hospital Pediatrics of BSMU bears the name of Professor E.N. Tretyakova with honor.
The main scientific activities of the department: 1. The state of health of young children with perinatal pathology. A comprehensive assessment of the health status of newborns and young children who have undergone various forms of perinatal pathology (congenital malformations, operative delivery by caesarean section, neonatal resuscitation) is carried out. The indicators and structure of neonatal and infant mortality, clinical and physiological processes of adaptation, physical and psychomotor development, the state of immunity are determined.In newborns with various perinatal and postnatal diseases, comprehensive studies were conducted to assess the indicators of lipid peroxidation and antioxidant protection of the body, luminol-dependent chemiluminescence, the structure of urine, local and general immunity. Currently, due to the new requirements and the transition of registration of children with extremely low body weight (less than 1000.0 at birth), I agree according to the criteria of the World Health Organization (WHO), the department conducts research to assess the health and psychomotor development of this contingent of children in catamnesis up to 3 years old. The effectiveness of various methods of nutritional therapy of premature infants at the stages of their medical care is evaluated.
2. The quality of life of children of different ages: regional standards, the influence of biomedical and socio-hygienic factors. Comprehensive research is being conducted to study the state of health and quality of life of children of various ages (sci. rukov. – Prof. V.A. Malievsky, O.A. Malievsky, E.N. Akhmadeeva). Comprehensive population studies of the health and quality of life of children of various ages in the Republic of Bashkortostan for the first time allowed us to give a comprehensive, multidimensional medical and social characteristics of children's health; to determine population indicators of children's quality of life; to identify a set of factors that affect the quality of life and to determine diagnostic criteria that allow forming risk groups. The research made it possible to scientifically substantiate and develop practical measures to improve the health of children of the Republic of Bashkortostan on the basis of population indicators of their quality of life. The obtained results made it possible to form groups of medical and social risk for low quality of life, as well as to become the basis for a comprehensive assessment of the health status of the studied contingent of children. The results of the study are used in the formation of regional and sectoral programs in the field of children's health of the republic, taken into account in the state report "On the state of children's health in the Republic of Bashkortostan".
3. The role of genetic and environmental factors in the formation of somatic pathology in children. A number of cooperative studies are being conducted jointly with geneticists of the Republic of Bashkortostan to determine the role of genetic factors in the formation of somatic pathology in children (scientific supervisors - V.A. Malievsky, R.F. Gatiyatullin, O.A. Malievsky, A.A. Nizhevich). The significance of polymorphic variants of the ADAM33 gene in the formation of predisposition to bronchial asthma has been established. When analyzing the polymorphism of tumor necrosis factor-α (TNFA, LTA) genes in the development of juvenile arthritis, it was found that the GG genotype and the G allele of the polymorphic locus -308G>A of the TNFa gene are associated with an increased risk of developing juvenile arthritis.
In the study of the clinical and genetic characteristics of congenital dysfunction of the adrenal cortex in children in the Republic of Bashkortostan,"8 different mutations were identified in patients. It has been shown that each form of 21-hydroxylase deficiency is mainly characterized by its own spectrum of diagnostically significant mutations. The analysis of the features of the phenotypic manifestations of the identified mutations in patients with VDCN showed a pronounced correlation between the phenotype and the nature of the mutation.
4. Assessment and prediction of the course and outcomes of juvenile arthritis. Juvenile arthritis (JA) – chronic inflammatory diseases of the joints - are the most common rheumatic diseases among children, leading to a decrease in the quality of life, the development of functional insufficiency and disability. The leading pathogenetic mechanisms of UA are activation of immunocompetent cells and hyperproduction of proinflammatory cytokines. Various combinations of polymorphic variants of cytokine genes, cytokine receptors, and other T-cell receptors can determine both the clinical polymorphism of UA and the effectiveness of antirheumatic therapy, including anti-cytokine drugs. The study of immunogenetic features (gene polymorphism and expression of cytokines, activators and inhibitors of T-cell activity), the state of cytokine status, clinical polymorphism, outcomes and socio-economic consequences of juvenile arthritis, evaluation and prediction of the effectiveness and safety of anti-cytokine drugs.
The department has a student scientific circle (assistant professor O.A.Bryukhanova). It should be noted that in recent years, an increasing number of students have shown an active interest in research work on pediatrics. During the academic year, meetings of the circle are held regularly (1 time per month) according to the approved work plan. Students – members of the SNC prepare reports on the issues discussed, presenting them in the form of multimedia presentations. At the annual final student scientific conferences, completed student scientific papers are presented in the form of reports. The work of the circle members of the SNK of the hospital department is annually marked with diplomas.